Poster #RP201
OMA Browser - Exploring Orthologous Relations across 290 Complete Genomes
Christophe Dessimoz*, Adrian Schneider*, Alexander Roth*, Emanuele Costa*, Gaston Gonnet*
*ETH Zurich, Switzerland
Elucidation of the evolutionary relation between proteins is a central challenge in comparative genomics. Although homology, the common ancestry of two or more sequences, can be easily assessed through sequence alignment, many comparative genomics analysis require more precise knowledge about the evolutionary relation of such sequences, in particular, distinction of orthologs from paralogs. Using results from the OMA project (1), we introduce here the OMA Browser (2), a web-based tool enabling the exploration of orthologous relations over more than 290 complete genomes. An original feature of the tool, besides its large scope, is the possibility, in cases of N:M orthology, to obtain the set of orthologs with respect to a protein of interest.
References:
(1) C Dessimoz, GM Cannarozzi, M Gil, D Margadant, A Roth, A Schneider and GH Gonnet, 2005: OMA, A Comprehensive, Automated Project for the Identification of Orthologs from Complete Genome Data: Introduction and First Achievements, LNCS 3678: Comparative Genomics: RECOMB 2005 International Workshop, RCG 2005, Dublin, Ireland.
(2) http://www.cbrg.ethz.ch/oma/omabrowser