Poster #RP211
The SWISS-MODEL expert system for protein structure homology modeling
Lorenza Bordoli*, Konstantin Arnold*, Jürgen Kopp*, Torsten Schwede*
*SIB Swiss Institute of Bioinformatics, University Basel, Switzerland
SWISS-MODEL (http://swissmodel.expasy.org) is a web-based integrated service dedicated to protein structure homology modelling. Homology modelling is generally the most accurate method to generate reliable three-dimensional protein structure models and is routinely used in many practical applications. The SWISS-MODEL Workspace provides a personal working environment, where the user can carry out several modelling projects in parallel. The necessary resources for homology modelling: up-to-date protein sequence and structure databases and specialized tools for template selection, model building and structure quality evaluation are accessible using a web interface. The accuracy of models build by SWISS-MODEL is continuously evaluated by the EVAcm project. The SWISS-MODEL Repository is a database of annotated three-dimensional comparative protein structure models generated by the fully automated homology-modelling pipeline. The Repository provides instant web-based access to annotated models, bridging the gap between sequence and structure databases.